Hot sale Ibrutinib intermediate Cas 330792-70-6

Product introduction

Product name: 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

Cas: 330792-70-6

MF: C₁₆H₁₂N₄O

Appearance: Light yellow to off-white powder

Assay: ≥98.5%

Maxium single impurity: ≤1.0%

Total impurity: ≤0.2%

Loss on drying: ≤1.0％

Residue on ignition: ≤0.2%

Heavy metals: ≤20ppm

Molecular Weight: 276.29

Application: 3-Amino-5-(4-phenoxyphenyl)-4-cyano-1H-pyrazole is an intermediate used in the synthesis of ibrutinib, which is a Bruton's tyrosine kinase (BTK) inhibitor for the treatment of chronic lymphocytic leukemia (CChemicalbookLL) and mantle cell lymphoma (MCL). Ibrutinib can target BTK necessary for the formation, differentiation, information transmission and survival of B lymphocytes, irreversibly inhibit the activity of BTK, and effectively inhibit the proliferation and survival of tumor cells.

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