Lapatinib Ditosylate Powder

Lapatinib ditosylate powder cas 388082-78-8 is the ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity.

Description

Product introduction

CAS: 388082-78-8

MF: C41H40ClFN4O11S3

Molecular Weight: 925.5 g/mol

Applications: Antimalarial drug, anti-cancer drug

Description: Lapatinib ditosylate powder cas 388082-78-8 is the ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity.

Application: Lapatinib ditosylate powder cas 388082-78-8 reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.


Certificate of analysis

Test items

Standards

Results

Appearance

Yellow powder

Conforms

Identification

IR

Conforms

Melting point

242-249℃

245.5-247.6℃

Total impurities

≤1.0%

0.6%

Loss on drying

≤1.0%

0.2%

Heavy metals

≤20ppm

Conforms

Assay

≥99.0%

99.4%


Company Information

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