Inhibitor LOXO-292

Selpercatinib Inhibitor LOXO-292 cas 2152628-33-4 is an oral and selective investigational new agent that is being evaluated for the treatment of patients with cancers that harbor alterations in the RET kinase in the LIBRETTO-001 trial (NCT03157128).

Description

Product introduction

CAS: 2152628-33-4

MF: C29H31N7O3

Molecular Weight: 525.6

Synoyms: LOXO292, Selpercatinib, LY3527723, CPD2206

Description: Selpercatinib Inhibitor LOXO-292 cas 2152628-33-4 is an oral and selective investigational new agent that is being evaluated for the treatment of patients with cancers that harbor alterations in the RET kinase in the LIBRETTO-001 trial (NCT03157128).

Application: Treat advanced tumors, histiocytic disorders that have activating RET gene alterations. Selpercatinib block the growth of cancer cells that have specific genetic changes in an important signaling pathway (called the RET pathway) and may reduce tumor size.

Other chemical names: SELPERCATINIB, Selpercatinib(LOXO-292)


Certificate of analysis

TETS

STANDARD

RESULTS

Appearance

White to off-white powder

White powder

LC/MS

Conformity with the structure

Conform

NMR

Conformity with the structure

Conform

Loss on drying

≤0.5%

0.21%

Related substances by

HPLC

Single impurity≤ 0.5%

Total impurities≤1.0%

0.3%

0.42%

Assay

Calculated on anhydrous basis, 98.0%~102.0%

99.3%


Company Information

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