Flumazenil Powder CAS 78755-81-4

Flumazenil powder cas 78755-81-4 has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zolpidem, zaleplon and zopiclone (also known as "Z-drugs").

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Description

Product introduction：

CAS: 78755-81-4

MF: C₁₅H₁₄FN₃O₃

Molecular Weight: 303.29

Perform Standard: USP

Melting point: 198℃ to 202℃

Assay(On dried substance): 99.0-101.0%

Application:

1、 Flumazenil powder cas 78755-81-4 has been used as an antidote in the treatment of benzodiazepine overdoses

2、 Flumazenil powder cas 78755-81-4 is also sometimes used after surgery to reverse the sedative effects of benzodiazepines.

3、Flumazenil powder cas 78755-81-4 has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zolpidem, zaleplon and zopiclone (also known as "Z-drugs").

4、Flumazenil powder cas 78755-81-4 is effective in reducing excessive daytime sleepiness while improving vigilance in primary hypersomnias, such as idiopathic hypersomnia.

5、Flumazenil powder cas 78755-81-4 has also been used in hepatic encephalopathy. It may have beneficial short‐term effects in people with cirrhosis, but there is no evidence for long-term benefits.

Other chemical names: RO 15-1788，FLUMAZENIL;RO 15-1788; RO15-1788，ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Certificate of analysia

Items	Specifications	Test Results
Appearance	White to a class of white powder	Conforms
Identification	The sample’S IR spectrum is according with spectrum of Flumazenil. The retention time of the major peak Flumazenil in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation .	Conforms Conforms
Melting point	198℃ to 202℃	199.6℃ to 200.7℃
Related substances	Known impurities	Impurity A: NMT 0.10% Impurity B: NMT 0.2% Impurity C: NMT 1.0%	Not detected 0.03% 0.02%
	Individual unknown impurity	NMT 0.10%	0.02%
	Total impurities	NMT 0.15%	0.07%
Loss on drying		NMT 0.5%	0.2%
Sulphated ash		NMT 0.1%	0.05%
Heavy metals		NMT 20ppm	5ppm
Bacterial endotoxins ( for injection )		NMT 0.56EU/mg	Conforms
Assay (On dried substance)		99.0-101.0%	99.93%
Guarantees the nature time		36 months
Conclusion		The test comply with the specification of USP32
Conclusion: the product conforms to the above specifications.