Entecavir Powder CAS 142217-69-4

Entecavir powder cas 209216-23-9 is an antiviral drug with activity against hepatitis B viral polymerase. As Entecavir powder cas 142217-69-4 is an analogue of the nucleoside guanosine, it competes with the enzyme's usual substrate.

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Description

Product introduction：

Cas:142217-69-4

Other names: entecavir hydrate, entecavir

Water: 5.8%—6.5%

Residue on ignition: ≤0.1％

Heavy metals: ≤20ppm

Assay: 98.0%--102..0%

Description: Entecavir powder cas 142217-69-4 is an antiviral drug with activity against hepatitis B viral polymerase. As Entecavir powder cas 209216-23-9 is an analogue of the nucleoside guanosine, it competes with the enzyme's usual substrate. This reduces the synthesis of viral DNA. Entecavir is therefore indicated when there is evidence of viral replication.

How it works: Entecavir powder cas142217-69-4 is a reverse transcriptase inhibitor that works by preventing the hepatitis B virus from multiplying and thereby decreasing the amount of the virus in the body. However, it is important to note that entecavir is not a cure for HBV and it may not prevent damage to the liver or reduce the chances of developing liver cancer. In addition, Entecavir powder cas 142217-69-4 doesn't prevent the spread of HBV to others through the normal routes of transmission, including sexual contact or exposure to blood or bodily fluids.

Other chemical names: Entecavir hydrate/entecavir, Entecavir Monohydrate IsoMers, 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate

Certificate of analysis

Items	Specifications	Results
Appearance	White to off-white powder	White powder
Identification	1)The IR absorption spectrum of the sample must be concordant with entecavir 2) RT of the sample should match that of standardin assay preparation	Conform
Identification	2) RT of the sample should match that of standard in assay preparation	Conform
Water	5.8%—6.5%	6.1%
Optical rotation	+24.0°—+28.0°(DMF: Me OH=1:1 c=1%)	+27.0°
Residue on ignition	≤0.1%	0.07%
Heavy metals	≤20ppm	＜20ppm
Related substances	Total impurities ≤0.3%	0.06%
Related substances	Any individual impurity≤0.1%	0.02%
Residual solvents	dichloromethane≤600ppm methanol≤3000ppm ethyl acetate≤5000ppm toluene≤890ppm	not detected 200ppm not detected not detected
Assay	98.0%--102..0%	99.9%
Particle size	95% of the particles should be within 125um	Conform

Entecavir powder cas 142217-69-4 packing

1. 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2. 5kg/carton(1kg net weight, 1.1kg gross weight, packed in five aluminum foil bag)
3. 25kg/drum (25kg net weight, 28kg gross weight; packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)