Entecavir Powder CAS 209216-23-9

Entecavir powder cas 209216-23-9 is an antiviral drug with activity against hepatitis B viral polymerase. As Entecavir powder cas 209216-23-9 is an analogue of the nucleoside guanosine, it competes with the enzyme's usual substrate.

Description

Product introduction

Cas: 209216-23-9

Other names: entecavir hydrate, entecavir

MF: C12H17N5O4

Molecular Weight: 295.29448

Water: 5.8%—6.5%

Residue on ignition: ≤0.1%

Heavy metals: ≤20ppm

Assay: 98.0%--102..0%

Description: Entecavir powder cas 209216-23-9 is an antiviral drug with activity against hepatitis B viral polymerase. As Entecavir powder cas 209216-23-9 is an analogue of the nucleoside guanosine, it competes with the enzyme's usual substrate. This reduces the synthesis of viral DNA. Entecavir is therefore indicated when there is evidence of viral replication.

How it works: Entecavir powder cas 209216-23-9 is a reverse transcriptase inhibitor that works by preventing the hepatitis B virus from multiplying and thereby decreasing the amount of the virus in the body. However, it is important to note that entecavir is not a cure for HBV and it may not prevent damage to the liver or reduce the chances of developing liver cancer. In addition, Entecavir powder cas 209216-23-9 doesn't prevent the spread of HBV to others through the normal routes of transmission, including sexual contact or exposure to blood or bodily fluids.

Other chemical names: Entecavir hydrate/entecavir, Entecavir Monohydrate IsoMers, 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate


Certificate of analysis

Items

Specifications

Results

Appearance

White to off-white powder

White powder

Identification

1)The IR absorption spectrum of the sample must be

concordant with entecavir

2) RT of the sample should match that of standardin assay

preparation

Conform


2) RT of the sample should match that of standard in assay

preparation

Conform

Water

5.8%—6.5%

6.1%

Optical rotation

+24.0°—+28.0°(DMF: Me OH=1:1 c=1%)

+27.0°

Residue on ignition

≤0.1%

0.07%

Heavy metals

≤20ppm

<20ppm

Related substances

Total impurities ≤0.3%

0.06%

Any individual impurity≤0.1% 0.02%

Residual solvents

dichloromethane≤600ppm

methanol≤3000ppm

ethyl acetate≤5000ppm

toluene≤890ppm

not detected

200ppm

not detected

not detected

Assay

98.0%--102..0%

99.9%

Particle size

95% of the particles should be within 125um

Conform


Company Information

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